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1

Structure–activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists

Vijay K. Gore, Vu V. Ma, Ruoyuan Yin, Joe Ligutti, David Immke, Elizabeth M. Doherty, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 834 KB

english, 2010

2

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

Hanh Nho Nguyen, Howie Bregman, John L. Buchanan, Bingfan Du, Elma Feric, Liyue Huang, Xingwen Li, Joseph Ligutti, Dong Liu, Annika B. Malmberg, David J. Matson, Jeff S. McDermott, Vinod F. Patel, Ben

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

3

The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR

Howard Bregman, Hanh Nho Nguyen, Elma Feric, Joseph Ligutti, Dong Liu, Jeff S. McDermott, Ben Wilenkin, Anruo Zou, Liyue Huang, Xingwen Li, Stefan I. McDonough, Erin F. DiMauro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.62 MB

english, 2012

4

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists

Nagasree Chakka, Howie Bregman, Bingfan Du, Hanh Nho Nguyen, John L. Buchanan, Elma Feric, Joseph Ligutti, Dong Liu, Jeff S. McDermott, Anruo Zou, Stefan I. McDonough, Erin F. DiMauro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.16 MB

english, 2012

5

PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR Spectroscopy

Poppe, Leszek, Hui, John O., Ligutti, Joseph, Murray, Justin K., Schnier, Paul D.

Journal:

Analytical Chemistry

Year:

2012

Language:

english

File:

PDF, 1.07 MB

english, 2012

6

Automated Tight Seal Electrophysiology for Assessing the Potential hERG Liability of Pharmaceutical Compounds

Tao, Huimin, Santa Ana, David, Guia, António, Huang, Mingxian, Ligutti, Joseph, Walker, George, Sithiphong, Khachonesine, Chan, Florence, Guoliang, Tao, Zozulya, Zoya, Saya, Steve, Phimmachack, Rick,

Journal:

Assay and Drug Development Technologies

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

7

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na V 1.7 Sodium Channel

Murray, Justin K., Ligutti, Joseph, Liu, Dong, Zou, Anruo, Poppe, Leszek, Li, Hongyan, Andrews, Kristin L., Moyer, Bryan D., McDonough, Stefan I., Favreau, Philippe, Stöcklin, Reto, Miranda, Les P.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.68 MB

english, 2015

8

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Murray, Justin K., Biswas, Kaustav, Holder, J. Ryan, Zou, Anruo, Ligutti, Joseph, Liu, Dong, Poppe, Leszek, Andrews, Kristin L., Lin, Fen-Fen, Meng, Shi-Yuan, Moyer, Bryan D., McDonough, Stefan I., Mi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1023 KB

english, 2015

9

A Christian Policy for Agriculture

Journal:

American Journal of Economics and Sociology

Year:

1956

Language:

english

File:

PDF, 261 KB

english, 1956

10

The Talents of Humble Folk

Journal:

American Journal of Economics and Sociology

Year:

1955

Language:

english

File:

PDF, 147 KB

english, 1955

11

Meeting the Needs of Rural Youth || Keep Youth on the Land

Journal:

The Phi Delta Kappan

Year:

1943

Language:

english

File:

PDF, 262 KB

english, 1943

12

Single Residue Substitutions That Confer Na V Subtype Selectivity in the Na V 1.7 Inhibitory Peptide GpTx-1

Murray, Justin K., Long, Jason, Zou, Anruo, Ligutti, Joseph, Andrews, Kristin L, Poppe, Leszek, Biswas, Kaustav, Moyer, Bryan D, McDonough, Stefan I, Miranda, Les P

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

13

Land Policy of the Holy See

Luigi G. Ligutti

Journal:

American Journal of Economics and Sociology

Year:

1966

Language:

english

File:

PDF, 1.29 MB

english, 1966

14

Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na V 1.7 inhibitors

Sparling, Brian A., Yi, S., Able, J., Bregman, H., DiMauro, Erin F., Foti, R. S., Gao, H., Guzman-Perez, A., Huang, H., Jarosh, M., Kornecook, T., Ligutti, J., Milgram, B. C., Moyer, B. D., Youngblood

Journal:

Year:

2017

Language:

english

File:

PDF, 980 KB

english, 2017

15

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na V 1.7

Kornecook, Thomas J, Yin, Ruoyuan, Altmann, Stephen, Be, Xuhai, Berry, Virginia, Ilch, Christopher P, Jarosh, Michael, Johnson, Danielle, Lee, Josie H, Lehto, Sonya G, Ligutti, Joseph, Liu, Dong, Luth

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

16

Discovery of a biarylamide series of potent, state-dependent Na V 1.7 inhibitors

Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moye

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

17

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates

Biswas, Kaustav, Nixey, Thomas E, Murray, Justin K., Falsey, James R, Yin, Li, Liu, Hantao, Gingras, Jacinthe, Hall, Brian E., Herberich, Brad, Holder, Jerry Ryan, Li, Hongyan, Ligutti, Joseph, Lin, M

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.84 MB

english, 2017

18

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Moyer, Bryan D., Murray, Justin K., Ligutti, Joseph, Andrews, Kristin, Favreau, Philippe, Jordan, John B., Lee, Josie H., Liu, Dong, Long, Jason, Sham, Kelvin, Shi, Licheng, Stöcklin, Reto, Wu, Bin, Y

Journal:

Year:

2018

Language:

english

File:

PDF, 6.80 MB

english, 2018

19

Discovery of Tarantula Venom-Derived Na V 1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Wu, Bin, Murray, Justin K., Andrews, Kristin L., Sham, Kelvin, Long, Jason, Aral, Jennifer, Ligutti, Joseph, Amagasu, Shanti, Liu, Dong, Zou, Anruo, Min, Xiaoshan, Wang, Zhulun, Ilch, Christopher P.,

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.04 MB

english, 2018

20

Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1

Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurelie H, Biswas, Kaustav, Craik, David J, Miranda, Les P, Troeira Henriques, Sonia, Schroeder, Christina

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 5.08 MB

english, 2018

21

Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins

Pajouhesh, H., Beckley, J. T., Delwig, A., Hajare, H. S., Luu, G., Monteleone, D., Zhou, X., Ligutti, J., Amagasu, S., Moyer, B. D., Yeomans, D. C., Du Bois, J., Mulcahy, J. V.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.06 MB

2020